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doi: 10.3389/fncir.2018.00014 Received 04 August 2017 Accepted 29 January 2018 Published 27 February 2018 Volume 12 - 2018 Edited by Paul J

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Protein misfolding and aggregation A defining feature of many NDDs is the accumulation of misfolded, aggregation-prone proteins (A and tau in AD, -synuclein in PD, SOD1/TDP-43 in ALS, etc.) [53]

FIGURE 5 Following the experimental design from the study of Moharrami Kasmaie et al., 2019, a 200 g rat injected intraperitoneally with 10 mg/kg of melatonin would receive 2 mg of melatonin

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