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Mitochondria DNA mutations and mitochondrial dysfunction have been associated with hepatic steatosis, metabolic syndrome, and obesity ( In previous studies, we have shown that intraperitoneal injections of nicotine when combined with a high-fat diet (HFD) triggers greater oxidative stress, activates hepatocyte apoptosis, and amplifies hepatic steatosis ( The effects of DNA damage on metabolism is an area of intense research

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