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The efficacy of antifolate antimalarial combinations in Africa: a predictive model based on pharmacodynamic and pharmacokinetic analyses

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It highlights thiamines (B1) role in catalyzing enzymes such as Pyruvate Dehydrogenase and -Ketoglutarate Dehydrogenase, (e) riboflavins (B2) contribution to fumarate production, and niacins (B3) importance in the synthesis of -Ketoglutarate and succinate ( (d) Electron Transport Chain, emphasizing niacins (B3) role in redox reactions and riboflavins (B2) function as an electron-shuttling cofactor ( The pentose phosphate pathway, through the action of transketolase (TK), converts ribose-5-phosphate to glyceraldehyde-3-phosphate (40)