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Hence, it had undergone negative selection against self-antigens within the thymus of the donor, and, not surprisingly, we did not observe any off-target activity in the patient

J Immunol Methods (2013) 390(1-2):928

However, this may change dramatically under some conditions, e.g., in patients with high-dose methotrexate therapy, an anticancer drug that, by inhibiting dihydrofolate reductase, inhibits the tetrahydrofolate-catalyzed recycling of methionine from homocysteine

If you want a broader look at how delivery affects absorption, our All About Liposomes guide is a helpful place to start

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No claims of effect, efficacy, or use outside of lawful research context are implied