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A B12 deficiency takes years to manifest because the body builds up significant reserves of B12, with the majority being stored in the liver, around 4-5 mg

doi:10.1097/gme.0b013e3181b8e02d

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miRNA is a novel gene regulator, and since miR-451 is amplified in HT patients and may lead to hypothyroidism, it is a highly significant molecule in the pathogenesis of HT