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As currently constructed, the model replicates the overall lung volumes, ventilatory characteristics, and environmental physiology of a breathing lung, but lacks the airway and alveolar structures required to emulate the distributive airflow features and particle deposition that are inherent to human lungs 48,49

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Methods Participants The dataset used for the present study was selected from the IMAGEN project, which was a prospective, multicentre longitudinal imaging genetics study that recruited 2000 healthy adolescents

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