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First, given that the aim of cMRTPs is to replace cigarettes, studies should always compare the effects of a cMRTP with those caused by cigarettes and, whenever possible, use smoking cessation as the benchmark as outlined previously [6]

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We can find the first hint of Poussins reasoning if we read deeper into Pliny

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Tobacco smoke: Involvement of reactive oxygen species and stable free radicals in mechanisms of oxidative damage, carcinogenesis and synergistic effects with other respirable particles

C., Suh, R., Sofuoglu, M., & Aquino, J