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Another school of thought suggests possible chemical alterations of the surfactant phospholipid composition and structure due to interactions with gaseous components from cigarette smoke 69,70

IL-6 mediates the JAKSTAT pathway, resulting in STAT3 phosphorylation, promoting neutrophil adhesion and migration to the lungs, releasing neutrophil elastase and matrix metalloproteinase-9, causing emphysema and COPD

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