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KPV additionally supports gut barrier epithelial integrity through epithelial cell-protective and tight junction-promoting activity, and provides antimicrobial activity against a range of pathogens relevant to gastrointestinal and skin health addressing the microbial dimension of gut dysbiosis and skin conditions that frequently co-occur with inflammatory gut barrier dysfunction

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A key mechanistic aim of the study was to investigate evidence that changes in MRS measures of glutamate might originate from impaired GABA restraint of glutamate neurons and resultant excitotoxic damage as first proposed in the NMDA receptor deficiency hypothesis of Olney and Farber [4]

Alcohol cravings, anxiety and insomnia are well-known triggers for relapse