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Similarly, IQOS elicited lower toxicity in all aspects than CS on lung epithelial cells and induced only 7.6% of the CS computationally estimated perturbation of gene expression 62

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Biomaterials 2010, 31, 58135824

In the aforementioned study exposing human gingival fibroblasts to CS condensate or to nicotine-rich or nicotine-free e-vapour condensates [29], the detrimental effects were greater in cells exposed to nicotine-rich condensate than to nicotine-free condensate, suggesting that the possible injurious effects of nicotine should be considered when purchasing e-refills