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This phenomenon is often exploited in cancer treatments, where therapies aim to increase ROS levels beyond a threshold that cancer cells can tolerate, effectively inducing their death while sparing normal cells [9]

In particular, PAH is characterized by remodeling of the ECM and thickening of all three layers of the PA wall ( Vascular stiffening has also been attributed to vascular calcification ( Figure 1 )

10.1021/acs.jmedchem.8b00315 157 LiC.LiuY

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