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These compounds bind to specific receptors in the brain

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These agents should be used in conjunction with long-acting medications such as NRT patches, varenicline, or bupropion

Nicotine patches, especially the 24 h compared to the 16 h ones, significantly increase the proportion of slow-wave sleep, REM density and REM beta activities, and decrease REM latency and N2 sleep stage duration [105,109,110]

For patients treated to the maximum recommended dose of 1 mg twice daily following initial dosage titration, the incidence of nausea was 30% compared with 10% in patients taking a comparable placebo regimen

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