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Study on the mechanism of mitigating radiation damage by improving the hematopoietic system and intestinal barrier with Tenebrio molitor peptides

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Atorvastatin also improved microvascular reactivity and reduced the oxidative stress marker malondialdehyde in patients with HFpEF (Iacovelli et al., 2024), and Simvastatin significantly decreased protein carbonylation (an oxidative stress marker) in COPD patients

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Persistent STAT3 activation can induce antiapoptotic proteins (e.g., Bcl-2 and Mcl-1) and angiogenic factors [e.g., vascular endothelial growth factor (VEGF)], forming a microenvironment conducive to tumor growth

Upon binding, IGF-1R activates two downstream pathways: the PI3K/Akt pathway (driving protein synthesis and glucose uptake) and the MAPK/ERK pathway (promoting cell proliferation and differentiation)