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Nicotine, which is made naturally by tobacco plants, but can also be synthetically produced, can cause a chemical addiction in people who use tobacco products, such as cigarettes, or nicotine-infused products, such as cartridges for electronic cigarettes

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Association of electronic cigarette use with initiation of combustible tobacco product smoking in early adolescence

Characterization of tobacco withdrawal symptoms: transdermal nicotine reduces hunger and weight gain

Fluctuations in mood are pronounced, causing emotional instability

The more chemicals contained in an e-liquid, the more toxic it was likely to be, the authors wrote