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These sophisticated systems range from 10 to 1000 nm and show unique properties that change how compounds work with skin tissue [6]

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Clarification of the role of these channels in glutamate release will require the generation of conditional knockout mice, in which TREK1 or TWIK1 channels are removed specifically in astrocytes, thus providing a suitable system to assess their participation in neuroprotection or glutamate excitotoxicity (Heurteaux et al., 2004

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