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Although they do not contain tar or emit carbon monoxide, they do contain other harmful substances, such as formaldehyde

Reynolds removed sensory cooling agents from their California-marketed Newport non-menthol varieties

In line with this, it has been observed that cigarette smoke induces the release of TNF- in an in vitro macrophage model system 56 , but others found no increased release of TNF- peripheral blood mononuclear cells to cigarette smoke extracts 57

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