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Supplementary Data 2 - Methods Table 2 summarizes the datasets used, criteria for selecting DEGs, p -values, fold-changes, GSE numbers, and data details

Treatment with anti-somatostatin antibodies or co-infusion with a somatostatin receptor 2 antagonist eliminated the GLP- 1-mediated suppression of glucagon secretion [71]

Human IL10 gene repression by Rev-erb ameliorates Mycobacterium tuberculosis clearance

So the limit seems to be about two weeks of regular use before you'd want to take a break of about two weeks

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American Journal of Physiology, 279: L994L1002