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Nevertheless, progressive recovery of nerve and elimination of fatigue can require 3-6 months or even more depending on the duration of the appearance of symptoms

de Rothschild, Paris, France, 10 Neurology Department, Hpital Lariboisire, Paris, France, 11 Universit Paris Cit, Paris, France, 12 INSERM, U1144, Paris, France, 13 FHU NeuroVasc, Paris, France, 14 Department of Neurology, Foch Hospital, Versailles Saint-Quentin en Yvelines University, Suresnes, France, 15 Department of Diagnostic and Therapeutic Neuroradiology, Universit de Lorraine, CHRU-Nancy, Nancy, France, 16 Universit de Lorraine, INSERM 1254, IADI, Nancy, France Background and Aims: Time from symptom onset to puncture (TSOP) and time from puncture to reperfusion (TPTR) are associated with worse outcome in ischemic stroke patients treated with endovascular therapy (EVT) in the early window ( 6 h), where EVT may benefit patients with favorable imaging profiles is unknown (late window paradox)

It works by stimulating growth factors, promoting angiogenesis (new blood vessel formation), and modulating the inflammatory response

the inventors also surprisingly found inhibitory activity with certain embodiments of the invention where R 1 is methyl with dual positional substitutions (see e.g., compounds 2j, 2m, 2k, and 2l, Table 2)

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