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In some cases, the affinity optimization is aimed at increasing the affinity by at least 2-fold, at least 3-fold, at least 4-fold, at least 5-fold, at least 6-fold, at least 7-fold, at least 8-fold, at least 9-fold, at least 10-fold, at least 20-fold, at least 30-fold, at least 40-fold, at least 50-fold, at least 100-fold, at least 500-fold, or at least 1,000-fold or more as compared to the affinity of the original antibody

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Antidepressants are restricted to selective serotonin reuptake inhibitors (SSRI) and serotonin and noradrenalin reuptake inhibitors (SNRI) and remain unchanged for at least 2 weeks before entering the trial (sertraline 50-200 mg/d, paroxetine 10-60 mg/d, citalopram 20-60 mg/d, venlafaxine 75-300 mg/d, duloxetine 30-90 mg/d)

BPC 157 is studied for its potential to directly counteract this by promoting the growth of the very vascular networks needed for robust repair

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