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recently revealed that in response to UV stress, studies in both cultured mammalian cells and mouse models have demonstrated that SIRT7-mediated deacetylation of nucleophosmin (NPM), a nucleolar protein released from the nucleolus in response to stress stimuli, is essential for stabilizing the tumor suppressor p53, ultimately promoting cell cycle arrest and DNA repair to suppress tumorigenesis

Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies