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Vascular endothelial cells produce and secrete many physiologically active substances including vasodilators, such as nitric oxide (NO), prostaglandin I 2 , C-type natriuretic peptide, and endothelium-derived vascular hyperpolarizing factor, and vasoconstrictors, such as endothelin, angiotensin II, prostaglandin H 2 and thromboxane A 2 [51, 52]

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Oral Infections Infections such as gingivitis (gum disease) or oral thrush (a fungal infection) can disrupt the balance of bacteria in your mouth, leading to inflammation and a bitter taste