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When viewed in this context, it led us to ask whether parkin-dependent, redox-based mechanisms could explain heretofore unresolved findings from unbiased, proteomic-based investigations of parkin-deficient mice

small onset and spread differences are real but rarely clinically significant

FASEB J 17:22022208 Porter NA, Caldwell SE, Mills KA (1995) Mechanisms of free radical oxidation of unsaturated lipids

3.1.2 Roles of ROS in the pathophysiology of other diseases 3.1.2.1 Liver diseases The liver is the second largest organ in the organisms body

Unaltered levels of glutathione status in lung tissue of ApoE -/- mice after pulmonary exposure to CB and/or LPS As a measure of oxidative stress, total and reduced glutathione were measured in lung homogenate 24 h after last exposure (Fig 3)

CRC stem cells have higher levels of cysteine, GSH, and SLC7A11 and, therefore, exhibit lower levels of ROS as compared to CRCs