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Geralyn Dexter points out that the combination pill poses an added risk because of the synthetic estrogen it contains.This in turn significantly raises cardiovascular risk for female smokers, and even more so for female smokers over age 35

But the higher temperatures also can trigger a thermal breakdown of the solvents, producing the carbonyls, explains Maciej Goniewicz of the Roswell Park Cancer Institute in Buffalo, N.Y

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J Pers Med 12(12):2064 Bendtsen L (2000) Central sensitization in tension-type headachepossible pathophysiological mechanisms

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