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If iron accumulation is observed, measurement of the iron content and genetic testing can eliminate hereditary hemochromatosis as the cause

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Therefore, improving the gut microbiota or supplementation with probiotics is expected to alleviate ADHD symptoms by increasing the production of neurotransmitters in the gut, reducing intestinal inflammation, and reducing the abundance of intestinal pathogens

Although system ferritin increasement is related to inflammatory states, such as malignancy, infection, and autoimmune diseases [167], the indices of systemic iron metabolism in ferroptosis-targeted therapy are uncertain

In contrast, it is well established that OS increases with age and can lead to cognitive impairment 14 , with OS playing an important role in Alzheimers disease (AD) onset and progression 15,16

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