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IL-33 cytokine is required for HBV plus DEN-induced liver cancer development To investigate the role of IL-33 in HBV+DEN-induced liver cancer, we subjected Il33 knockout (Il33 KO ), ST2 knockout (ST2 KO ), and Il33 transcription factor, Irf3 , knockout (Irf3 KO ) mice to HBV+DEN liver carcinogenesis protocol (Fig

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