Sima AA Acetyl-L-carnitine in diabetic polyneuropathy: experimental and clinical data.CNS Drugs
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Use with caution in patients with hormone-sensitive tumors or cancers
In 1934, Whipple, Minot and Murphy were awarded the Nobel Prize for Physiology and Medicine for discovering the anti pernicious anemia factor, named extrinsic factor
Polycystic Ovary Syndrome (PCOS) - 5-10% of women 50% lower glutathione levels compared to women without PCOS 3-4x higher risk of preeclampsia 3x higher risk of gestational diabetes Critical concern: With 50% lower baseline glutathione, the "safe" dose is effectively cut in half IVF Conception - 2-5% of births (up to 6-8% in some countries) Women who conceive via IVF experience dramatic antioxidant depletion: 70% reduction in plasma antioxidant capacity 83% reduction in follicular fluid antioxidant capacity 50-100%+ increase in oxidative stress markers With over 5 million babies born via IVF globally, this represents a large high-risk population Gallbladder Dysfunction - 10% of pregnant women Up to 10% develop gallstones or biliary sludge Intrahepatic cholestasis: 0.4-10% of pregnancies CRITICAL: Fatal Outcomes Documented at Therapeutic Doses The first case of a pregnant woman with intrahepatic cholestasis who died from liver failure after taking THERAPEUTIC/NORMAL doses of acetaminophen was reported in 2022
Reduced Oxidative Damage: SS-31 minimizes the production of reactive oxygen species (ROS), stabilizing mitochondrial membranes and shielding vital tissues such as the heart, skeletal muscle, and kidneys from oxidative stress
