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In metabolic disease, nutrient overload and ER stress elevate H 2 O 2 /O 2 , coupling lipotoxicity to ferroptotic risk when labile iron expands (Schieber and Chandel 2014)

The findings of this research will guide further investigations into the diagnostic and prognostic implications of blood metabolites for IBD subtypes

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Nonetheless, somatic topoisomerase 2 enzyme has the ability to interfere with this arrangement by turning the DNA coils in a different direction

*Correspondence: Yongping Mu, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

These findings highlight PC liposomes as a promising Nutlin-3a delivery system for managing proliferative vitreoretinal diseases [185] (Table 5)