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We need large studies observing patients randomized to treatments tracking outcomes based on imaging data so that imaging can prove its utility above the standard of care

PMID: 19136019 PMID: 12834882 Reference Reading Foundational Design Paper 1989 Cyclic-lactam -MSH analogs including Melanotan II origin and melanotropic potency Al-Obeidi, Castrucci, Hadley, and Hruby reported the design and synthesis of the 23-membered lactam-bridged cyclic heptapeptide (this compound) and documented 100-fold enhanced melanotropic potency vs -MSH in the lizard skin bioassay

In a mutant mouse model of depression, a dysregulated OXPHOS pathway was seen in the hippocampus (Zubenko et al., 2014), which is a key region of dampened plasticity in both human depression and rodent models (Sheline et al., 2003