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Fe 3+ absorbed into the cell is located in the endosomes and is reduced to ferrous iron (Fe 2+ ) by transmembrane epidermal antigen of prostate 3 (STEAP3) [70]

FcRn-ligand complexes are instead sorted into vesicles that traffic back to the plasma membrane and undergo exocytosis 42,43,44,45,46,49

doi: 10.2174/0115734072286081240326082701 79 YiY-S

Nat Cell Biol 9(8):858867 Horton ER, Byron A, Askari JA, Ng DHJ, Millon-Frmillon A, Robertson J et al (2015) Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly

Nilsson et al., 2014)

Deficiency has also been linked with a higher likelihood of pre-eclampsia, gestational diabetes and excess weight gain during pregnancy