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Disclosures: Donghyun Ko: Nothing to Disclose, Do Han Kim: Nothing to Disclose, Sharon Narvaez: Nothing to Disclose, Luis Nieto: Nothing to Disclose, Pedro Palacios Argueta: Nothing to Disclose, Paul Kroner: Nothing to Disclose, Frank Lukens: Nothing to Disclose 2122 PROGRAMMED CELL DEATH FACTOR 4 AGGRAVATES SEPSIS-INDUCED LIVER DAMAGE THROUGH DISTURBED MITOCHONDRIAL QUALITY CONTROL SYSTEM Jiachi Yu 1 ruibing li 1 , 1 Department of Clinical Laboratory Medicine, The First Medical Centre, Medical School of Chinese PLA Background: Sepsis is the most common cause of death in intensive care units, caused by deregulated immune response to infection