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van Noord, P

Primary & Secondary Bile Acids: Thyroid hormones help to regulate the rate of bile acid synthesis as well as flow of bile acids from liver, into gallbladder, and into the intestinal tract Secondary bile acids, initially triggered by thyroid hormones, impact energy metabolism by influencing insulin sensitivity and thus blood sugar regulation as well as activating D2 (the T4 to T3 enzyme)

Mitochondrial dysfunction and oxidative stress in aging and cancer

Current challenges in NADs development Unlike traditional small molecules and antibody drugs that exert their pharmacological effects on proteins, most NADs directly regulate gene expression, offering a broader range of targets

Andrews SN, Jeong E, Prausnitz MR

WalczakJedrzejowskaRWolskiJKSlowikowskaHilczerJ