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Side effects These may include: feeling sick (nausea) vomiting appetite changes and difficulty swallowing sore mouth or mouth ulcers skin and nail changes numbness in the hands or feet ringing in the ears or hearing loss constipation or diarrhoea, and hair loss or thinning

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MOTS-c activates AMPK through the AICAR accumulation pathway described earlier

This work was supported by the Swedish Research Council (2022-03681, to P.S.), the Novo Nordisk Foundation (NNF20OC0064789, to P.S.), the Swedish Brain Foundation (to P.S.), the Wellcome Trust (204954/Z/16/Z, to M.A.C.), the Australian Research Council (ARC

Different mechanisms, different costs, different evidence bases