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Originally derived from the bone marrow, DCs travel as precursors through the blood circulation, migrate to peripheral tissues, such as the lung, and position themselves as immature cells just beneath the epithelial layers (Figure 1b)

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Taken together, DNA methylation at any given CpG is the result of multiple processes that are orchestrated as a developmental cascade involving, first, global demethylation after fertilization, then, cell/tissue-specific re-methylation during very early embryogenesis and, finally, maintenance of DNA methylation throughout the remainder of life

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Certain factors smoking, EBV infection and obesity interact with HLA risk genes, pointing at a pathogenetic pathway involving adaptive immunity