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The observed lack of a significant accumulation of PHN in brain following the intraventricular administration of (+)-amphetamine and the formation of appreciable amounts of PHN from (+)-POH in brain tissue in vivo supports the view that the aromatic hydroxylation of amphetamine following its systemic administration occurs predominantly in the periphery, and that POH is then transported through the blood-brain barrier, taken up by noradrenergic neurones in brain where (+)-POH is converted in the storage vesicles by dopamine -hydroxylase to PHN

Simon The pipesters across the pond say la-TAC-ee-ah, but the transliteral spelling of the port city in Syria puts an apostrophe before the q in Lata Qiyah, so the American pronunciation would be the more correct one

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