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Establishing causality requires large-scale prospective cohort studies that enroll initially healthy individuals, quantitatively assess baseline MNPs exposure, and longitudinally track incident CVDs outcomes

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The phospholipid bilayer of the platelet membrane (PM) hosts specific receptors that enable direct interactions with vascular injury sites, contributing to immune evasion, and mediating drug responses [4]

Along trajectory B, which reflects the conversion from IL7R low naive CD4 T cells to CD4 T-dividing cells, primary metabolic process (GO:0044238)-related genes, such as RAN , SEC11A , and B2M , were highly expressed following L-serine administration (Fig

This review critically evaluates these complexities, establishing frameworks to reconcile conflicting data and prioritize translationally viable metabolites