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The large velvety, oval leaves (10-35 x 3-15 cm), are grey-green on the upper surface, and white to yellowish underneath with prominent ears (25mm) at base which clasp the stem

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Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors

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Singer and colleagues 5759 were among the first to show that experimental animals could be trained to self-administer small intravenous doses of nicotine

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