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These cytokines, associated with activated polymorphonuclear leukocytes (PMNs) and their derived proteases, destroy newly developing tissue and degrade key growth factors

doi: 10.1038/cddis.2017.480

Exp Lung Res 36:548557

Prajapat M, Sarma P, Shekhar N, Avti P, Sinha S, Kaur H, et al

Recent developments in automated sampling of blood (159) and tissue interstitial fluid via microdialysis (160) have also uncovered the ultradian rhythms in plasma ACTH which correlate well with plasma and tissue steroid (cortisol and cortisone) concentrations, indicating that the ultradian rhythms in blood ACTH and cortisol/cortisone translate well to tissue exposure to these steroids

ROS can induce AP-1, a heterodimer composed of c-fos and c-jun, which downregulates type I collagen and upregulates MMPs in aging skin [77], and can also inhibit the TGF- signaling pathway in skin fibroblasts