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Sample size calculation The required sample size was estimated to be 363 (min 272) based on the prevalence of IBS in the general population being estimated to be 13% with an estimated error of 4%, Type 1 error (alpha) 5% (two-tailed), power 95%, and allowing for a 25% dropout rate

That position held for years until now

Loon sold several products that used the names, flavors, and images of candy, including cotton candy, banana taffy, berry lemon bubble gum, and pomegranate lemon drop: Loon also marketed and sold vape products that used the names, flavors, and images of kid-friendly beverages, including Mountain Dew (Mountain Dude), Red Bull (Bad Bull), and Fanta (Orange Fantasie): Loon also marketed and sold vape products that used the names, flavors, and images of desserts, like popsicles and vanilla custard: In addition to using kid-friendly food flavors, Loon also uses kid-friendly characters and imagery in marketing and selling vape products, including Bowser from Super Mario (Bowzer Berry), Frankenstein, dragons, and a Purple Blitz product that appears to reference the Minnesota Vikings: Loon sold these products in both English- and Spanish-language packaging and descriptions that highlighted the candy, soda, dessert, characters, and other youth-appealing aspects of the vape products

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