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Myeloma cells exhibit a metabolic phenotype characterized by enhanced glycolytic flux for ATP production, glucose to lactate conversion and reduced mitochondrial OXPHOS (166168)

Gautham Reddy 6 Christophe Corpechot 7 Susheela Carroll 8 Ke Yang 9 Daria Crittenden 8 Charles McWherter 9 , 1 Liver Institute Northwest, 2 California Pacific Medical Center, 3 Weill Cornell Medical College, New York, NY, 4 California Liver Reasearch Institiute, 5 Beth Israel Deaconess Medical Center, Boston, MA, 6 University of Chicago Medical Center, 7 Saint-Antoine Hospital, Paris, France, 8 CymaBay Therapeutics Inc, 9 CymaBay Therapeutics Background: Alkaline phosphatase (ALP) is an important marker in primary biliary cholangitis (PBC) associated with risk for disease progression

Marketing sometimes promotes unrealistic timelines that set false expectations

Cancer Res 58:53405343 Izakovicova Holla L, Stejskalova A, Vasku A (2006) Polymorphisms of the GSTM1 and GSTT1 genes in patients with allergic diseases in Czech population

Of these, 2 patients had 100 % necrosis, 3 had 50% obstruction of one or more coronary arteries on angiogram

and Jansen, C.A.M