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Khanna is with Medstar Georgetown University Hospital Department of Dermatology in Washington, District of Columbia

Lysosomal exocytosis, a mechanism of content secretion into the extracellular space, is mediated by lysosomal fusion with the cell plasma membrane that enables cargo release

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Despite these findings, substrate availability may also play a role in reducing GSH synthesis rates, because Sekhar et al showed partial restoration of RBC-GSH concentrations and absolute synthesis rates in uncontrolled type 2 diabetes after cysteine and glycine supplementation [16]