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These include liver and colorectal cancer, diabetes mellitus, ectopic pregnancy, erectile dysfunction, age-related macular degeneration, orofacial clefts in newborns (as a result of maternal smoking), rheumatoid arthritis, and health problems such as inflammation and impaired immune functioning

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Unlike FDA-approved nicotine replacement therapy, which is a safe and potentially effective smoking cessation method in adults, there is no strong evidence that electronic cigarettes and similar products are effective smoking cessation aids