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Description

despite a short plasma half-life (~2 minutes in rodents), ARA-290 crosses the BBB and exerts central neurological effects Neural and cognitive processing Cerit H et al

Mechanism of action Direct renin inhibitors competitively inhibit human renin, which decreases plasma renin activity and inhibits the conversion of angiotensinogen to angiotensin I

The outcome of this process is the formation of self-assembled matrices with interwoven nanofibers

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