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In this study, small molecule-targeted drugs were used to simultaneously inhibit PI3K/mTOR and CDK, triggering pyroptosis in cancer cells and thereby enhancing the effectiveness of immune therapy

However, both groups showed reduced tumor cell viability, with a stronger effect in the NF1 exon-skipping group, indicating synergy (Fig

Research has shown that heightened oxidative stress in individuals with DM is linked to iron imbalances due to decreased iron-binding antioxidant capacity [58]