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Importantly, the treatment response was related to baseline homocysteine levels such that individuals with levels above 13 mol/L exhibited greater reductions in the rate of brain atrophy with B-vitamin supplementation than those with lower homocysteine levels

This sustained ADO production may contribute to a tolerogenic BM niche that promotes immune evasion and therapeutic resistance

Metabolic effects of a synthetic lipolytic domain derived from human growth hormone (AOD-9604). Journal of Endocrinology, 2000

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