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GSH is also a key determinant of redox signaling, vital in detoxification of xenobiotics, regulates cell proliferation, apoptosis, immune function, and fibrogenesis

[DOI] [PMC free article] [PubMed] [Google Scholar] 127.Vergara F., Wenzler M., Hansen B.G., Kliebenstein D.J., Halkier B.A., Gershenzon J., Schneider B

12 ] In humans, melatonin production often declines with age, which may contribute to sleep disturbances and disruptions in normal biological timing

It plays a central role in oxidative-stress defense, phase II detoxification, and redox homeostasis

This intrinsic connectivity implies that ferroptosis is not merely a simple 'death switch' but rather a composite reflection of the overall metabolic state of the cell