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10.1371/journal.pone.0216385 49 DludlaP

Opposite effects of bromelain were also reported, such as those blocking signal transduction through Raf-1/MEK/ERK-2 signaling pathway in stimulated T helper cells (126)

Infected mice exhibit characteristic anxiety and depressive-like behaviors correlated with reduced antioxidant enzymes (SOD, GSH) and elevated malondialdehyde (MDA) levels, indicating ROS-mediated lipid peroxidation