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these receptors are found on the surface of endothelial and inflammatory cells and play a role in both pro- (such as insulin receptors) (238, 239) and anti-inflammatory (glucocorticoid receptors) (240242) responses, respectively

doi: 10.1093/advances/nmaa073

Moreover, Bcl-2 expression in the hippocampus was increased after 14 days of administration of citalopram, promethazine, and amitriptyline (Kosten et al., 2008), which suggests that potential antidepressants could be developed through an anti-apoptotic mechanism

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