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Ipamorelin is a selective growth hormone-releasing peptide (GHRP) that acts on the ghrelin receptor (GHS-R1a) to stimulate pituitary somatotrophs through a mechanism independent of GHRH signaling

Cellular assays have enabled detailed examination of second messenger dynamics, such as cyclic AMP generation and calcium mobilization, while animal models have provided insight into systemic signal coordination and feedback regulation along the hypothalamic pituitary axis

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