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Ultrasound-guided direct delivery of 3-bromopyruvate blocks tumor progression in an orthotopic mouse model of human pancreatic cancer

Ait Tayeb, A

The sedimented liquid layer containing tumescent fluid and blood components was discarded

Taken together, our work suggests that the glutamine-glutamate cycle and KRAS-dependent modulation of FOXO signalling are potentially attractive new targets for validation studies in more clinically relevant models and drug discovery

TBH (300 mg/kg) was intraperitoneal injected into mice for 3 h or 16 h