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The three classes are: Critical Semi-critical, and Noncritical

[PubMed: 445452] Hoffmann D, Adams JD, Brunnemann KD, Hecht SS

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(ii) that producers of the complaining Member could have adapted to the requirements of the technical regulation at issue within the shorter interval that it allowed

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The primary end-point was defined as a biologically verified reduction of 50% in the average number of smoked cigarettes per day during week 21-24 compared to baseline